SLC5A6

Solute carrier family 5 member 6
المعرفات
الأسماء المستعارة	Na+-dependent multivitamin transporter, sodium-dependent multivitamin transporter, solute carrier family 5 (sodium-dependent vitamin transporter), member 6, Na(+)-dependent multivitamin transporter, SLC5A6, solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
معرفات خارجية
أورثولوج
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

SLC5A6‏ (Solute carrier family 5 member 6) هوَ بروتين يُشَفر بواسطة جين SLC5A6 في الإنسان.^[1]^[2]^[3]^[4]

الوظيفة عدل

الأهمية السريرية عدل

المراجع عدل

^ Uchida Y، Ito K، Ohtsuki S، Kubo Y، Suzuki T، Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. ج. 134 ع. 1: 97–112. DOI:10.1111/jnc.13092. PMID:25809983.
^ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6". مؤرشف من الأصل في 2010-12-05.
^ Wang H، Huang W، Fei YJ، Xia H، Yang-Feng TL، Leibach FH، Devoe LD، Ganapathy V، Prasad PD (يوليو 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. ج. 274 ع. 21: 14875–83. DOI:10.1074/jbc.274.21.14875. PMID:10329687.
^ Prasad PD، Wang H، Kekuda R، Fujita T، Fei YJ، Devoe LD، Leibach FH، Ganapathy V (أبريل 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. ج. 273 ع. 13: 7501–6. DOI:10.1074/jbc.273.13.7501. PMID:9516450.

قراءة متعمقة عدل

Prasad PD، Wang H، Huang W، وآخرون (1999). "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter". Arch. Biochem. Biophys. ج. 366 ع. 1: 95–106. DOI:10.1006/abbi.1999.1213. PMID:10334869.
Zempleni J، Steven Stanley J، Mock DM (2001). "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of Nutritional Biochemistry. ج. 12 ع. 8: 465–473. DOI:10.1016/S0955-2863(01)00162-0. PMID:11834205.
Dey S، Subramanian VS، Chatterjee NS، وآخرون (2002). "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochim. Biophys. Acta. ج. 1574 ع. 2: 187–92. DOI:10.1016/s0167-4781(02)00226-9. PMID:11955628.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Balamurugan K، Ortiz A، Said HM (2003). "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. ج. 285 ع. 1: G73–7. DOI:10.1152/ajpgi.00059.2003. PMID:12646417.
Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
Balamurugan K، Vaziri ND، Said HM (2005). "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". Am. J. Physiol. Renal Physiol. ج. 288 ع. 4: F823–31. DOI:10.1152/ajprenal.00375.2004. PMID:15561972.
Otsuki T، Ota T، Nishikawa T، وآخرون (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. ج. 12 ع. 2: 117–26. DOI:10.1093/dnares/12.2.117. PMID:16303743.
Luo S، Kansara VS، Zhu X، وآخرون (2006). "Functional Characterization of Sodium-dependent Multivitamin Transporter (SMVT) in MDCK-MDR1 cells and its Utilization as a Target for Drug Delivery". Mol. Pharm. ج. 3 ع. 3: 329–39. DOI:10.1021/mp0500768. PMC:2553563. PMID:16749865.
Reidling JC، Nabokina SM، Said HM (2007). "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. ج. 292 ع. 1: G275–81. DOI:10.1152/ajpgi.00327.2006. PMID:16959947.
Reidling JC، Said HM (2007). "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". Am. J. Physiol., Cell Physiol. ج. 292 ع. 4: C1305–12. DOI:10.1152/ajpcell.00360.2006. PMID:17135299.

هذه بذرة مقالة عن جين على كروموسوم 2 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[Uchida_2015-1] Uchida Y، Ito K، Ohtsuki S، Kubo Y، Suzuki T، Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. ج. 134 ع. 1: 97–112. DOI:10.1111/jnc.13092. PMID:25809983.

[entrez-2] "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6". مؤرشف من الأصل في 2010-12-05.

[pmid10329687-3] Wang H، Huang W، Fei YJ، Xia H، Yang-Feng TL، Leibach FH، Devoe LD، Ganapathy V، Prasad PD (يوليو 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. ج. 274 ع. 21: 14875–83. DOI:10.1074/jbc.274.21.14875. PMID:10329687.

[pmid9516450-4] Prasad PD، Wang H، Kekuda R، Fujita T، Fei YJ، Devoe LD، Leibach FH، Ganapathy V (أبريل 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. ج. 273 ع. 13: 7501–6. DOI:10.1074/jbc.273.13.7501. PMID:9516450.

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