FCGR2A
بروتين في الإنسان العاقل
FCGR2A (Fc fragment of IgG receptor IIa) هوَ بروتين يُشَفر بواسطة جين FCGR2A في الإنسان.[1][2]
Fc fragment of IgG receptor IIa | |||||||
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المعرفات | |||||||
الأسماء المستعارة | Fc-gamma RII-a, low affinity immunoglobulin gamma Fc region receptor II-a, Fc gamma receptor RIIa3, FCGR2A, igG Fc receptor II-a, fcRII-a, Immunoglobulin G Fc receptor II, fc-gamma-RIIa, CDw32, Fc fragment of IgG, low affinity IIa, receptor (CD32) | ||||||
معرفات خارجية | |||||||
أورثولوج | |||||||
الأنواع | الإنسان | الفأر | |||||
أنتريه | n/a | ||||||
Ensembl | n/a | n/a | |||||
يونيبروت |
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RefSeq (مرسال ر.ن.ا.) |
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RefSeq (بروتين) |
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الموقع (UCSC | n/a | ||||||
بحث ببمد | n/a | ||||||
ويكي بيانات | |||||||
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الوظيفةعدل
هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريريةعدل
هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجععدل
- ^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". مؤرشف من الأصل في 2009-05-10.
- ^ "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. يونيو 1990. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID 2139735.
قراءة متعمقةعدل
- McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders". Blood Rev. 16 (1): 3–5. doi:10.1054/blre.2001.0170. PMID 11913983.
- "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J. Biol. Chem. 267 (22): 15692–700. 1992. PMID 1379234.
- Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor". Immunogenetics. 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077.
- "Quantification of macrophage cell surface molecules in rheumatoid arthritis". Clin. Exp. Immunol. 77 (1): 47–51. 1989. PMC 1541930. PMID 2527651.
- "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes". J. Exp. Med. 170 (4): 1369–85. 1989. doi:10.1084/jem.170.4.1369. PMC 2189488. PMID 2529342.
- "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science. 246 (4937): 1611–3. 1990. Bibcode:1989Sci...246.1611L. doi:10.1126/science.2531919. PMID 2531919.
- "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. 166 (6): 1668–84. 1987. doi:10.1084/jem.166.6.1668. PMC 2188792. PMID 2824655.
- "Molecular cloning of a human immunoglobulin G Fc receptor". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2240–4. 1988. Bibcode:1988PNAS...85.2240H. doi:10.1073/pnas.85.7.2240. PMC 279966. PMID 2965389.
- "The PI-linked receptor FcRIII is released on stimulation of neutrophils". Nature. 333 (6174): 667–9. 1988. Bibcode:1988Natur.333..667H. doi:10.1038/333667a0. PMID 2967437.
- "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1". Immunogenetics. 28 (5): 380–1. 1988. doi:10.1007/BF00364238. PMID 2971615.
- "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning". EMBO J. 7 (4): 1053–9. 1988. PMC 454434. PMID 3402431.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. 1996. doi:10.1074/jbc.271.18.10775. PMID 8631888.
- "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans". J. Clin. Invest. 97 (5): 1348–54. 1996. doi:10.1172/JCI118552. PMC 507190. PMID 8636449.
- "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. 1996. PMC 231474. PMID 8756631.
- "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway". J. Biol. Chem. 271 (48): 30499–504. 1997. doi:10.1074/jbc.271.48.30499. PMID 8940017.
- "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. 1997. doi:10.1016/S0167-4889(97)00034-7. PMID 9268059.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. 91 (6): 2108–17. 1998. PMID 9490697.