PDGFB

PDGFB
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1PDG, 3MJG, 4HQU, 4HQX, 4QCI
المعرفات
الأسماء المستعارة	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 190040 MGI: MGI:97528 HomoloGene: 74303 GeneCards: 5155
علم الوجود الجيني
الوظيفة الجزيئية	• protein homodimerization activity; • protein heterodimerization activity; • chemoattractant activity; • platelet-derived growth factor receptor binding; • platelet-derived growth factor binding; • superoxide-generating NADPH oxidase activator activity; • growth factor activity; • identical protein binding; • collagen binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
المكونات الخلوية	• platelet alpha granule lumen; • سيتوبلازم; • الفراغ خارج الخلية; • Golgi membrane; • basolateral plasma membrane; • cell surface; • endoplasmic reticulum lumen; • غشاء; • ‏GO:0005578 نسيج بيني خارج الخلية; • خارج خلوي; • تجويف غولجي; • collagen-containing extracellular matrix;
العمليات الحيوية	• activation of protein kinase B activity; • positive regulation of DNA biosynthetic process; • positive regulation of chemotaxis; • cellular response to growth factor stimulus; • positive regulation of protein tyrosine kinase activity; • peptidyl-tyrosine phosphorylation; • positive regulation of cell division; • نماء القلب; • positive regulation of glomerular filtration; • positive regulation of mitotic nuclear division; • positive regulation of MAP kinase activity; • positive regulation of metanephric mesenchymal cell migration; • positive regulation of hyaluronan biosynthetic process; • MAPK cascade; • protein phosphorylation; • positive regulation of glomerular mesangial cell proliferation; • cellular response to mycophenolic acid; • positive regulation of fibroblast proliferation; • activation of protein kinase activity; • نمو متعدد الخلايا; • positive regulation of protein autophosphorylation; • positive regulation of reactive oxygen species metabolic process; • عملية التمثيل الغذائي لأنواع الأكسجين التفاعلية; • ‏GO:0045996 negative regulation of transcription, DNA-templated; • protein kinase C signaling; • metanephric glomerular mesangial cell development; • negative regulation of phosphatidylinositol biosynthetic process; • response to wounding; • positive regulation of phosphatidylinositol 3-kinase activity; • cell chemotaxis; • positive regulation of ERK1 and ERK2 cascade; • platelet degranulation; • ضبط زيادي للتكاثر الخلوي; • positive regulation of DNA replication; • ‏GO:1901313 positive regulation of gene expression; • embryonic placenta development; • تأشير نظير صماوي; • monocyte chemotaxis; • positive regulation of endothelial cell proliferation; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of calcium ion import; • ‏GO:0060469، ‏GO:0009371 positive regulation of transcription, DNA-templated; • ‏GO:0035404 peptidyl-serine phosphorylation; • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; • positive regulation of blood vessel endothelial cell migration; • تكون الدم; • positive regulation of cell migration; • positive regulation of peptidyl-tyrosine phosphorylation; • extracellular matrix organization; • negative regulation of protein binding; • positive regulation of MAPK cascade; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of platelet activation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of vascular associated smooth muscle cell migration; • positive chemotaxis; • negative regulation of vascular associated smooth muscle cell differentiation; • interleukin-18-mediated signaling pathway; • positive regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of gene expression; • positive regulation of smooth muscle cell migration; • positive regulation of smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell dedifferentiation; • platelet-derived growth factor receptor signaling pathway; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of platelet-derived growth factor receptor-beta signaling pathway; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P01127
	P31240
	‏NM_002608، ‏XM_047441393، ‏XM_047441394 NM_033016، ‏NM_002608، ‏XM_047441393، ‏XM_047441394
	‏XM_006520592، ‏XM_017316502 NM_011057، ‏XM_006520592، ‏XM_017316502
	‏NP_148937 NP_002599، ‏NP_148937
	‏XP_006520655، ‏XP_030104269، ‏XP_030104270، ‏XP_030104271، ‏XP_036015133، ‏XP_036015134 NP_035187، ‏XP_006520655، ‏XP_030104269، ‏XP_030104270، ‏XP_030104271، ‏XP_036015133، ‏XP_036015134
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

PDGFB‏ (Platelet derived growth factor subunit B) هوَ بروتين يُشَفر بواسطة جين PDGFB في الإنسان.^[1]^[2]

الوظيفة عدل

الأهمية السريرية عدل

المراجع عدل

^ Clements JM، Bawden LJ، Bloxidge RE، Catlin G، Cook AL، Craig S، Drummond AH، Edwards RM، Fallon A، Green DR (يناير 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. ج. 10 ع. 13: 4113–20. PMC:453161. PMID:1661670.
^ Ratner L، Josephs SF، Jarrett R، Reitz MS، Wong-Staal F (سبتمبر 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. ج. 13 ع. 14: 5007–18. DOI:10.1093/nar/13.14.5007. PMC:321845. PMID:2991848.

قراءة متعمقة عدل

Kurup S، Abramsson A، Li JP، Lindahl U، Kjellen L، Betsholtz C، Gerhardt H، Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. ج. 34 ع. Pt 3: 454–5. DOI:10.1042/BST0340454. PMID:16709185.

هذه بذرة مقالة عن جين على كروموسوم 22 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid1661670-1] Clements JM، Bawden LJ، Bloxidge RE، Catlin G، Cook AL، Craig S، Drummond AH، Edwards RM، Fallon A، Green DR (يناير 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. ج. 10 ع. 13: 4113–20. PMC:453161. PMID:1661670.

[pmid2991848-2] Ratner L، Josephs SF، Jarrett R، Reitz MS، Wong-Staal F (سبتمبر 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. ج. 13 ع. 14: 5007–18. DOI:10.1093/nar/13.14.5007. PMC:321845. PMID:2991848.

[1]

[2]