FOXA2

Forkhead box A2
المعرفات
الأسماء المستعارة	TCF-3B, hepatic nuclear factor-3-beta, forkhead box protein A2, hepatocyte nuclear factor 3-beta, transcription factor 3B, HNF-3-beta, HNF-3B, FOXA2
معرفات خارجية
أورثولوج
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

FOXA2‏ (Forkhead box A2) هوَ بروتين يُشَفر بواسطة جين FOXA2 في الإنسان.^[1]^[2]^[3]

الوظيفة عدل

الأهمية السريرية عدل

المراجع عدل

^ "Entrez Gene: forkhead box A2". مؤرشف من الأصل في 2010-12-05.
^ Wang H، Gauthier BR، Hagenfeldt-Johansson KA، Iezzi M، Wollheim CB (مايو 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. ج. 277 ع. 20: 17564–70. DOI:10.1074/jbc.M111037200. PMID:11875061.
^ Mincheva A، Lichter P، Schütz G، Kaestner KH (فبراير 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. ج. 39 ع. 3: 417–9. DOI:10.1006/geno.1996.4477. PMID:9119385.

قراءة متعمقة عدل

Zhang Y، Ali TZ، Zhou H، وآخرون (2010). "ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer". Cancer Res. ج. 70 ع. 1: 240–8. DOI:10.1158/0008-5472.CAN-09-2904. PMC:3724404. PMID:20048076.
Lee HS، Bae EJ، Yi SH، وآخرون (2010). "Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival". Stem Cells. ج. 28 ع. 3: 501–12. DOI:10.1002/stem.294. PMID:20049900.
Akagi T، Luong QT، Gui D، وآخرون (2008). "Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells". Br. J. Cancer. ج. 99 ع. 5: 781–8. DOI:10.1038/sj.bjc.6604544. PMC:2528161. PMID:18682709.
Lamba V، Panetta JC، Strom S، Schuetz EG (2010). "Genetic predictors of interindividual variability in hepatic CYP3A4 expression". J. Pharmacol. Exp. Ther. ج. 332 ع. 3: 1088–99. DOI:10.1124/jpet.109.160804. PMC:2835441. PMID:19934400.
Popovic J، Klajn A، Petrovic I، Stevanovic M (2010). "Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression". Biochim. Biophys. Acta. ج. 1799 ع. 5–6: 411–8. DOI:10.1016/j.bbagrm.2010.01.002. PMID:20074681.
Dayoub R، Groitl P، Dobner T، وآخرون (2010). "Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells". Biochem. Biophys. Res. Commun. ج. 395 ع. 4: 465–70. DOI:10.1016/j.bbrc.2010.04.023. PMID:20382118.
Talmud PJ، Drenos F، Shah S، وآخرون (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. ج. 85 ع. 5: 628–42. DOI:10.1016/j.ajhg.2009.10.014. PMC:2775832. PMID:19913121.
Tabassum R، Chavali S، Dwivedi OP، وآخرون (2008). "Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians". J. Hum. Genet. ج. 53 ع. 11–12: 957–65. DOI:10.1007/s10038-008-0335-6. PMID:18797817.
Bochkis IM، Rubins NE، White P، وآخرون (2008). "Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress". Nat. Med. ج. 14 ع. 8: 828–36. DOI:10.1038/nm.1853. PMC:4095974. PMID:18660816.
Long Y، Chen E، Liu C، وآخرون (2009). "The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients". J. Viral Hepat. ج. 16 ع. 8: 537–46. DOI:10.1111/j.1365-2893.2009.01089.x. PMID:19302415.
Banerjee A، Meyer K، Mazumdar B، وآخرون (2010). "Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression". J. Virol. ج. 84 ع. 12: 5936–46. DOI:10.1128/JVI.02344-09. PMC:2876629. PMID:20357092.
Ishii K، Yoshida Y، Akechi Y، وآخرون (2008). "Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta". Hepatology. ج. 48 ع. 2: 597–606. DOI:10.1002/hep.22362. PMID:18666263.
Song Y، Washington MK، Crawford HC (2010). "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer". Cancer Res. ج. 70 ع. 5: 2115–25. DOI:10.1158/0008-5472.CAN-09-2979. PMC:2831111. PMID:20160041.
Howell JJ، Stoffel M (2009). "Nuclear export-independent inhibition of Foxa2 by insulin". J. Biol. Chem. ج. 284 ع. 37: 24816–24. DOI:10.1074/jbc.M109.042135. PMC:2757185. PMID:19589781.
Xing C، Cohen JC، Boerwinkle E (2010). "A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels". Am. J. Hum. Genet. ج. 86 ع. 3: 440–6. DOI:10.1016/j.ajhg.2010.01.025. PMC:2833364. PMID:20152958.
Martin CC، Flemming BP، Wang Y، وآخرون (2008). "Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression". J. Mol. Endocrinol. ج. 41 ع. 5: 315–28. DOI:10.1677/JME-08-0062. PMC:2614309. PMID:18753309.
Pandey AK، Bhardwaj V، Datta M (2009). "Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells". FEBS J. ج. 276 ع. 14: 3757–69. DOI:10.1111/j.1742-4658.2009.07091.x. PMID:19769745.
Uetzmann L، Burtscher I، Lickert H (2008). "A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm". Genesis. ج. 46 ع. 10: 515–22. DOI:10.1002/dvg.20410. PMID:18798232.
Bailey SD، Xie C، Do R، وآخرون (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. ج. 33 ع. 10: 2250–3. DOI:10.2337/dc10-0452. PMC:2945168. PMID:20628086.

هذه بذرة مقالة عن بروتين بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: forkhead box A2". مؤرشف من الأصل في 2010-12-05.

[pmid11875061-2] Wang H، Gauthier BR، Hagenfeldt-Johansson KA، Iezzi M، Wollheim CB (مايو 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. ج. 277 ع. 20: 17564–70. DOI:10.1074/jbc.M111037200. PMID:11875061.

[pmid9119385-3] Mincheva A، Lichter P، Schütz G، Kaestner KH (فبراير 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. ج. 39 ع. 3: 417–9. DOI:10.1006/geno.1996.4477. PMID:9119385.

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