English: Photomicrographs of coronal sections of a mouse brain stained with APP at 24h post brain injury (A,B). The box indicates the region of interest, which is shown at a higher magnification. Sagittal section of a mouse brain (C-H). Immunoreactive axonal profiles were observed as either granular (bulb) (B,G,H) or more elongated, fusiform (F) swellings at 24h post traumatic brain injury. Example of APP immunoreactive neurons (arrow heads) observed in the cortex underneath the impact site (E,G). No APP staining was observed in healthy control animals (D). Tissue sections were counterstained with hematoxylin.