تابينتادول: الفرق بين النسختين

[نسخة منشورة][نسخة منشورة]
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JarBot (نقاش | مساهمات)
JarBot (نقاش | مساهمات)
سطر 22:
| bioavailability = 31.9 ± 6.8% (oral)<ref>{{ مرجع كتاب | المؤلف = Terlinden, R.; Ossig, J.; Fliegert, F.; Gohler, K. | سنة = 2006 | chapter = Pharmacokinetics, Excretion and Metabolism of Tapentadol HCl, a Novel Centrally Acting Analgesic in Healthy Subjects | العنوان = Program and Abstracts of the 25th Annual Scientific Meeting of the American Pain Society; May 3–6, 2006 San Antonio, Texas | id = Poster 689 }}</ref>
| protein_bound = 20%<ref name = MD/>
| metabolism = Hepatic (mostly via [[glucuronidation]] but also by [[CYP2C9]], [[CYP2C19]], [[CYP2D6سيتوكروم 2D6]])<ref name = MD/>
| elimination_half-life = 4 hours<ref name = MD/>
| excretion = Urine (73%) and faeces<ref name = MD>{{cite web|title=Tapentadol|work=Martindale: The Complete Drug Reference|publisher=Pharmaceutical Press|date=14 November 2011|accessdate=2 April 2014|url=http://www.medicinescomplete.com/mc/martindale/current/ms-21327-p.htm|editor=Brayfield, A}}</ref>