إيميبرامين: الفرق بين النسختين
| [مراجعة غير مفحوصة] | [مراجعة غير مفحوصة] |
تم حذف المحتوى تمت إضافة المحتوى
ط بوت: ترحيل 14 وصلة إنترويكي, موجودة الآن في ويكي بيانات على d:q58396 |
لا ملخص تعديل وسمان: تحرير من المحمول تعديل ويب محمول |
||
سطر 1:
{{Drugbox
| verifiedrevid = 461936291
| IUPAC_name = 3-(10,11-dihydro-5''H''-dibenzo[''b,f'']azepin-5-yl)-''N'',''N''-dimethylpropan-1-amine
| image = Imipramine.svg
| width = 200
| image2 = Imipramine3DanBS.gif
| width2 = 250
<!--Clinical data-->
| tradename = Tofranil
| Drugs.com = {{drugs.com|monograph|imipramine-hydrochloride}}
| MedlinePlus = a682389
| pregnancy_AU = C
| pregnancy_US = N
| legal_AU = S4
| legal_US = Rx-only
| legal_CA = Rx-only
| legal_UK = POM
| routes_of_administration = Oral
<!--Pharmacokinetic data-->
| bioavailability = 94-96%<ref name = Pharm>{{cite journal|last=Heck|first=HA|author2=Buttrill, JE Jr |author3=Flynn, NW |author4=Dyer, RL |author5=Anbar, M |author6=Cairns, T |author7=Dighe, S |author8= Cabana, BE |title=Bioavailability of imipramine tablets relative to a stable isotope-labelled internal standard: increasing the power of bioavailability tests|journal=Journal of Pharmacokinetics and Biopharmaceutics|date=June 1979|year=1979|volume=7|issue=3|pages=233–248|pmid=480146|doi=10.1007/bf01060015}}</ref>
| protein_bound = 86%<ref name = TOLERADE />
| metabolism = [[Hepatic]] ([[CYP1A2]], [[CYP2C19]], [[CYP2D6]]) <br>Main active metabolite [[desipramine]]<ref name = TOLERADE>{{cite web|title=PRODUCT INFORMATION TOLERADE® (imipramine hydrochloride)|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-07434-3|work=TGA eBusiness Services|publisher=PMIP Pty Ltd|accessdate=16 October 2013|date=4 June 2013}}</ref>
| elimination_half-life = 20 hours<ref name = TOLERADE />
| excretion = [[Renal]] (80%), [[Faeces|Faecal]] (20%) (mostly as inactive metabolites)<ref name = TOLERADE />
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 50-49-7
| ATC_prefix = N06
| ATC_suffix = AA02
| PubChem = 3696
| IUPHAR_ligand = 357
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00458
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3568
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = OGG85SX4E4
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08070
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 47499
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 11
<!--Chemical data-->
| C=19 | H=24 | N=2
| molecular_weight = 280.407 g/mol
| smiles = c1cc3c(cc1)CCc2c(cccc2)N3CCCN(C)C
| InChI = 1/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
| InChIKey = BCGWQEUPMDMJNV-UHFFFAOYAX
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = BCGWQEUPMDMJNV-UHFFFAOYSA-N
}}
'''إيميبرامين''' {{إنج|Imipramine}} هو [دواء] اسمه التجاري توفرانيل {{إنج|Tofranil}} وينتمي هذا الدواء إلى [[مضادات الاكتئاب ثلاثية الحلقات]] ويستعمل كذلك في علاج [[التبول اللاإرادي]] عند الأطفال.
| |||