SFRP2

SFRP2
معرفات
أسماء بديلة	SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604157 MGI: MGI:108078 HomoloGene: 56438 GeneCards: 6423
علم الوجود الجيني
وظائف جزيئية	• fibronectin binding; • receptor ligand activity; • endopeptidase activator activity; • integrin binding; • ‏GO:0010577 enzyme activator activity; • G protein-coupled receptor activity; • Wnt-protein binding; • Wnt-activated receptor activity;
مكونات خلوية	• ‏GO:0005578 نسيج بيني خارج الخلية; • الفراغ خارج الخلية; • خارج خلوي; • مكون تكاملي للغشاء; • collagen-containing extracellular matrix;
عمليات حيوية	• cellular response to extracellular stimulus; • positive regulation of endopeptidase activity; • Wnt signaling pathway involved in somitogenesis; • تكون الجسيدات; • تمايز خلوي; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • male gonad development; • regulation of establishment of planar polarity; • response to nutrient; • collagen fibril organization; • convergent extension involved in axis elongation; • development of primary male sexual characteristics; • positive regulation of canonical Wnt signaling pathway; • negative regulation of mesodermal cell fate specification; • cellular response to X-ray; • cell-cell signaling; • negative regulation of Wnt signaling pathway; • bone morphogenesis; • hematopoietic stem cell proliferation; • chondrocyte development; • embryonic digit morphogenesis; • outflow tract morphogenesis; • cardiac left ventricle morphogenesis; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; • بروتين دبيلو.أن.تي; • negative regulation of gene expression; • sclerotome development; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of angiogenesis; • planar cell polarity pathway involved in neural tube closure; • negative regulation of BMP signaling pathway; • نمو متعدد الخلايا; • negative regulation of cardiac muscle cell apoptotic process; • regulation of apoptotic process; • positive regulation of cell growth; • neural tube closure; • negative regulation of peptidyl-tyrosine phosphorylation; • negative regulation of cell migration; • positive regulation of osteoblast differentiation; • regulation of Wnt signaling pathway; • تَكوّن الغُضروف; • regulation of cell population proliferation; • regulation of stem cell division; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • negative regulation of cell growth; • neural tube development; • ضبط زيادي للتكاثر الخلوي; • negative regulation of epithelial cell proliferation; • positive regulation of apoptotic process; • branching involved in blood vessel morphogenesis; • post-anal tail morphogenesis; • negative regulation of dermatome development; • negative regulation of planar cell polarity pathway involved in axis elongation; • positive regulation of cell adhesion mediated by integrin; • ‏GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of JUN kinase activity; • positive regulation of fat cell differentiation; • negative regulation of epithelial to mesenchymal transition; • negative regulation of cell population proliferation; • ‏GO:0003257، ‏GO:0010735، ‏GO:1901228، ‏GO:1900622، ‏GO:1904488 ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • digestive tract morphogenesis; • نقل شاردة الكالسيوم; • ‏GO:0097285 استماتة; • negative regulation of canonical Wnt signaling pathway; • regulation of midbrain dopaminergic neuron differentiation; • regulation of neuron projection development; • G protein-coupled receptor signaling pathway; • non-canonical Wnt signaling pathway; • regulation of signaling receptor activity; • canonical Wnt signaling pathway;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
تماثلات متسلسلة
	Q96HF1
	P97299
	NM_003013
	NM_009144
	NP_003004
	NP_033170
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

SFRP2‏ (Secreted frizzled related protein 2) هوَ بروتين يُشَفر بواسطة جين SFRP2 في الإنسان.^[1]^[2]

الوظيفة عدل

الأهمية السريرية عدل

المراجع عدل

^ "Entrez Gene: SFRP2 secreted frizzled-related protein 2". مؤرشف من الأصل في 2010-12-05.
^ Melkonyan HS، Chang WC، Shapiro JP، Mahadevappa M، Fitzpatrick PA، Kiefer MC، Tomei LD، Umansky SR (يناير 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. ج. 94 ع. 25: 13636–41. DOI:10.1073/pnas.94.25.13636. PMC:28358. PMID:9391078.

قراءة متعمقة عدل

Rattner A، Hsieh JC، Smallwood PM، وآخرون (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors". Proc. Natl. Acad. Sci. U.S.A. ج. 94 ع. 7: 2859–63. DOI:10.1073/pnas.94.7.2859. PMC:20287. PMID:9096311.
Hu E، Zhu Y، Fredrickson T، وآخرون (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas". Biochem. Biophys. Res. Commun. ج. 247 ع. 2: 287–93. DOI:10.1006/bbrc.1998.8784. PMID:9642118.
Lescher B، Haenig B، Kispert A (1999). "sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney". Dev. Dyn. ج. 213 ع. 4: 440–51. DOI:10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6. PMID:9853965.
Chang JT، Esumi N، Moore K، وآخرون (1999). "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium". Hum. Mol. Genet. ج. 8 ع. 4: 575–83. DOI:10.1093/hmg/8.4.575. PMID:10072424.
Lee CS، Buttitta LA، May NR، وآخرون (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. ج. 127 ع. 1: 109–18. PMID:10654605.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Clark HF، Gurney AL، Abaya E، وآخرون (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. ج. 13 ع. 10: 2265–70. DOI:10.1101/gr.1293003. PMC:403697. PMID:12975309.
Brophy PD، Lang KM، Dressler GR (2004). "The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor". J. Biol. Chem. ج. 278 ع. 52: 52401–5. DOI:10.1074/jbc.M305614200. PMID:14561758.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
Lee JL، Lin CT، Chueh LL، Chang CJ (2004). "Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis". J. Biol. Chem. ج. 279 ع. 15: 14602–9. DOI:10.1074/jbc.M309008200. PMID:14709558.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Müller HM، Oberwalder M، Fiegl H، وآخرون (2004). "Methylation changes in faecal DNA: a marker for colorectal cancer screening?". Lancet. ج. 363 ع. 9417: 1283–5. DOI:10.1016/S0140-6736(04)16002-9. PMID:15094274.
Brandenberger R، Wei H، Zhang S، وآخرون (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. ج. 22 ع. 6: 707–16. DOI:10.1038/nbt971. PMID:15146197.
Zhang Z، Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. ج. 13 ع. 10: 2819–24. DOI:10.1110/ps.04682504. PMC:2286551. PMID:15340161.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Otsuki T، Ota T، Nishikawa T، وآخرون (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. ج. 12 ع. 2: 117–26. DOI:10.1093/dnares/12.2.117. PMID:16303743.
Clément G، Braunschweig R، Pasquier N، وآخرون (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus". Oncogene. ج. 25 ع. 21: 3084–92. DOI:10.1038/sj.onc.1209338. PMID:16407829.
Urakami S، Shiina H، Enokida H، وآخرون (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. ج. 12 ع. 7 Pt 1: 2109–16. DOI:10.1158/1078-0432.CCR-05-2468. PMID:16609023.
Olsen JV، Blagoev B، Gnad F، وآخرون (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. ج. 127 ع. 3: 635–48. DOI:10.1016/j.cell.2006.09.026. PMID:17081983.
Huang ZH، Li LH، Yang F، Wang JF (2007). "Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions". World J. Gastroenterol. ج. 13 ع. 6: 950–4. DOI:10.3748/wjg.v13.i6.950. PMID:17352030.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Veeck J، Noetzel E، Bektas N، Jost E، Hartmann A، Knuchel R، Dahl E (2008). "Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer". Mol Cancer. ج. 7 ع. 83: 83. DOI:10.1186/1476-4598-7-83. PMC:2613402. PMID:18990230.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)

هذه بذرة مقالة عن جين على كروموسوم 4 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[1] "Entrez Gene: SFRP2 secreted frizzled-related protein 2". مؤرشف من الأصل في 2010-12-05.

[2] Melkonyan HS، Chang WC، Shapiro JP، Mahadevappa M، Fitzpatrick PA، Kiefer MC، Tomei LD، Umansky SR (يناير 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. ج. 94 ع. 25: 13636–41. DOI:10.1073/pnas.94.25.13636. PMC:28358. PMID:9391078.

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